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Olinciguat

Chemical Structure : Olinciguat

CAS No.: 1628732-62-6

Olinciguat (IW-1701, IW1701)

Catalog No.: PC-60523Not For Human Use, Lab Use Only.

Olinciguat (IW-1701, IW1701) is a novel potent, selective soluble guanylate cyclase (sGC) stimulator, enhances the synthesis of cGMP in response to NO binding.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Olinciguat (IW-1701, IW1701) is a novel potent, selective soluble guanylate cyclase (sGC) stimulator, enhances the synthesis of cGMP in response to NO binding.
Olinciguat attenuates increases in plasma biomarkers of endothelial cell activation and leukocyte‐endothelial cell interactions in TNFα‐challenged mice.
Olinciguat attenuates leukocyte‐endothelial cell interactions, improves blood flow and prolongs survival time in the Berkeley mouse model of TNFα‐induced vaso‐occlusive crisis.

Physicochemical Properties

M.Wt 509.4
Formula C21H16F5N7O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(2R)-3,3,3-trifluoro-2-{[(5-fluoro-2-{1-[(2-fluorophenyl)methyl]- 5-(1,2-oxazol-3-yl)-1H-pyrazol- 3-yl}pyrimidin-4-yl)amino]methyl}-2-hydroxypropanamide

References

1. Tchernychev B, et al. Br J Pharmacol. 2021 Sep;178(17):3463-3475.
2. Zimmer DP, et al. Front Pharmacol. 2020 Apr 8;11:419.

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