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Chemical Structure : Ozanimod
CAS No.: 1306760-87-1
Catalog No.: PC-42950Not For Human Use, Lab Use Only.
Ozanimod (RPC-1063) is a potent, selective agonist of S1P1 and S1P5 receptor with EC50 of 0.41 nM and 11 nM respectively.
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| 10 mg | $188 | In stock | |
| 25 mg | $298 | In stock | |
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Ozanimod (RPC-1063) is a potent, selective agonist of S1P1 and S1P5 receptor with EC50 of 0.41 nM and 11 nM respectively.
Ozanimod (RPC-1063) is less potent for S1P2, S1P3 and S1P4 (EC50> 10 uM).
Ozanimod (RPC-1063) induces S1P1 receptor internalization and induced a reversible reduction in circulating B and CCR7(+) T lymphocytes in vivo.
Ozanimod (RPC-1063) shows high oral bioavailability and volume of distribution, and a circulatory half-life.
| M.Wt | 404.4617 | |
| Formula | C23H24N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 29 mg/mL |
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| Chemical Name/SMILES |
Benzonitrile, 5-[3-[(1S)-2,3-dihydro-1-[(2-hydroxyethyl)amino]-1H-inden-4-yl]-1,2,4-oxadiazol-5-yl]-2-(1-methylethoxy)- |
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1. Scott FL, et al. Br J Pharmacol. 2016 Jun;173(11):1778-92.
2. Sandborn WJ, et al. N Engl J Med. 2016 May 5;374(18):1754-62.
3. Sandborn WJ, et al. N Engl J Med. 2016 Aug 25;375(8):e17.
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