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Chemical Structure : PD-146176
CAS No.: 4079-26-9
Catalog No.: PC-70225Not For Human Use, Lab Use Only.
PD-146176 (NSC 168807, PD146176) is a potent, selective, non-competitve inhibitor of 15-lipoxygenase (15-LOX) with Ki of 197 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | $528 | In stock | |
| 100 mg | Get quote |
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PD-146176 (NSC 168807, PD146176) is a potent, selective, non-competitve inhibitor of 15-lipoxygenase (15-LOX) with Ki of 197 nM.
PD-146176 shows no demonstrable effect on 5-LOX, 12-LOX, COX-1 or COX-2.
PD-146176 significantly abrogates SAT1-induced ferroptosis, inhibits amyloid β protein aggregate formation without changing total levels of amyloid β precursor protein (APP) in cells stably expressing APP.
| M.Wt | 237.3 | |
| Formula | C15H11NS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
6,11-dihydro-[1]benzothiopyrano[4,3-b]indole |
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1. Ou Y, et al. Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):E6806-E6812., et al.
2. Bocan TM, et al. Atherosclerosis. 1998 Feb;136(2):203-16.
3. Sendobry SM, et al. Br J Pharmacol. 1997 Apr;120(7):1199-206.
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