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Chemical Structure : PD-150606
CAS No.: 179528-45-1
Catalog No.: PC-42190Not For Human Use, Lab Use Only.
A potent and selective calpain inhibitor with Ki of 0.21 uM/0.37 uM for u-calpain/m-calpain, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $184 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | $592 | In stock |
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A potent and selective calpain inhibitor with Ki of 0.21 uM/0.37 uM for u-calpain/m-calpain, respectively; shows no inhibition for other proteases (cathepin B, papain, trypsin and thermolysin (Ki> 500 uM); attenuate shypoxic/hypoglycemic injury to cerebrocortical neurons in culture and excitotoxic injury to Purkinje cells in cerebellar slices.
| M.Wt | 306.1201 | |
| Formula | C9H7IO2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 28 mg/mL |
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| Chemical Name/SMILES |
2-Propenoic acid, 3-(4-iodophenyl)-2-mercapto-, (2Z)- |
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1. Wang KK, et al. Proc Natl Acad Sci U S A. 1996 Jun 25;93(13):6687-92.
2. Niapour M, et al. J Biol Chem. 2008 Aug 1;283(31):21371-81.
3. Waters SL, et al. J Pharmacol Exp Ther. 1997 Dec;283(3):1177-84.
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