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PDE5-IN-6c

Chemical Structure PDE5-IN-6c

CAS No.: 1448419-13-3

PDE5-IN-6c (PDE5 inhibitor 6c)

Catalog No.: PC-60093Not For Human Use, Lab Use Only.

A novel potent, selective PDE5 inhibitor with IC50 of 0.056 nM for PDE5A1.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

A novel potent, selective PDE5 inhibitor with IC50 of 0.056 nM for PDE5A1; displays >500-fold selectivity over PDE6; exhibits good efficacy in mouse model of Alzheimer's disease.

Physicochemical Properties

M.Wt 420.897
Formula C23H21ClN4O2
CAS No. 1448419-13-3
Storage
Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 1 Month
Shipping
Solubility

Chemical Name

2-Acetyl-10-((3-chloro-4-methoxybenzyl)amino)-1,2,3,4-tetrahydrobenzo[b][1,6]naphthyridine-8-carbonitrile

Clinical Information

References

1. Fiorito J, et al. J Med Chem. 2017 Nov 9;60(21):8858-8875.

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