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Chemical Structure : PF-06651600 malonate
Catalog No.: PC-62334Not For Human Use, Lab Use Only.
PF-06651600 malonate (Ritlecitinib) is a novel potent, selective JAK3 inhibitor with IC50 of 0.346 nM, displays >1,000-fold selectivity over JAK1 and JAK2.
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PF-06651600 malonate (Ritlecitinib) is a novel potent, selective JAK3 inhibitor with IC50 of 0.346 nM, displays >1,000-fold selectivity over JAK1 and JAK2.
PF-06651600 inhibits Th1 and Th17 cell differentiation and function, reduces disease pathology in rat adjuvant-induced arthritis as well as in mouse experimental autoimmune encephalomyelitis models.
PF-06651600 selectively targets γc cytokine pathways while preserving JAK1-dependent anti-inflammatory signaling such as the IL-10 suppressive functions following LPS treatment in macrophages and the suppression of TNFα and IL-1β production in IL-27-primed macrophages.
| M.Wt | 389.412 | |
| Formula | C18H23N5O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Telliez JB, et al. ACS Chem Biol. 2016 Dec 16;11(12):3442-3451.
2. Thorarensen A, et al. J Med Chem. 2017 Mar 9;60(5):1971-1993.
3. Robinette ML, et al. Mucosal Immunol. 2017 May 17. doi: 10.1038/mi.2017.38.
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