Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : PF-2771
CAS No.:
Catalog No.: PC-45640Not For Human Use, Lab Use Only.
PF-2771 is a potent, selective CENP-E inhibitor with IC50 of 16.1 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $400 | In stock | |
| 50 mg | $1200 | In stock | |
| 100 mg | $1680 | In stock |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
PF-2771 is a potent, selective CENP-E inhibitor with IC50 of 16.1 nM; does not inhibit the ATPase activities of highly related kinesins (Eg5/KSP, chromokinesin and MCAK, IC50> 1 uM); selectively inhibits proliferation of basal breast cancer cell lines; regresses tumor growth correlated with increased phospho-HH3-Ser10 levels in a breast cancer xenograft tumor model.
| M.Wt | 554.0803 | |
| Formula | C29H36ClN5O4 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
DMSO: ≥ 32 mg/mL |
|
| Chemical Name/SMILES |
(S)-N-(1-(4-(2-acetyl-1-methyl-1H-imidazol-4-yl)phenyl)-3-(2-(dimethylamino)acetamido)propan-2-yl)-3-chloro-4-isopropoxybenzamide |
|
1. Kung PP, et al. Mol Cancer Ther. 2014 Aug;13(8):2104-15.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
