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Chemical Structure : PF-470
Catalog No.: PC-61059Not For Human Use, Lab Use Only.
A highly potent, selective, and efficacious metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulator with Ki of 0.9 nM, IC50 of 2.5 nM.
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A highly potent, selective, and efficacious metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulator with Ki of 0.9 nM, IC50 of 2.5 nM; demonstrates robust efficacy in MPTP-rendered Parkinsonian nonhuman primate model of l-DOPA-induced dyskinesia (PD-LID), but with delayed-type immune-mediated type IV hypersensitivity.
| M.Wt | 332.367 | |
| Formula | C18H16N6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Zhang L, et al. J Med Chem. 2014 Feb 13;57(3):861-77.
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