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Chemical Structure : PF 05180999
CAS No.: 1394033-54-5
Catalog No.: PC-60564Not For Human Use, Lab Use Only.
PF-05180999 (PF 5180999) is a potent, selective, brain-penetrating and orally bioavailable phosphodiesterase 2A (PDE2A) inhibitor with IC50 of 1 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $148 | In stock | |
| 25 mg | $248 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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PF-05180999 (PF 5180999) is a potent, selective, brain-penetrating and orally bioavailable phosphodiesterase 2A (PDE2A) inhibitor with IC50 of 1 nM.
PF-05180999 displays >1,000-fold selectivity over PDE10.
PF-05180999 shows potential for treatment of schizophrenia.
| M.Wt | 414.396 | |
| Formula | C19H17F3N8 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-(1-Azetidinyl)-7-methyl-5-[1-methyl-5-[5-(trifluoromethyl)-2-pyridinyl]-1H-pyrazol-4-yl]-imidazo[5,1-f][1,2,4]triazine |
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1. Mikami S, et al. J Med Chem. 2017 Sep 28;60(18):7677-7702.
2. Helal CJ, et al. J Med Chem. 2018 Jan 2. doi: 10.1021/acs.jmedchem.7b01466.
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