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Chemical Structure : PFK15
CAS No.: 4382-63-2
Catalog No.: PC-42915Not For Human Use, Lab Use Only.
PFK15 (PFK 015) is a potent, selective 6-phosphofructo-2-kinase (PFKFB3) inhibitor with IC50 of 207 nM against recombinant human PFKFB3, displays 100-fold more activity than 3PO.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $128 | In stock | |
| 50 mg | $198 | In stock | |
| 100 mg | $298 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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PFK15 (PFK 015) is a potent, selective 6-phosphofructo-2-kinase (PFKFB3) inhibitor with IC50 of 207 nM against recombinant human PFKFB3, displays 100-fold more activity than 3PO.
PFK15 (PFK 015) does not inhibit PFK-1, hexokinase, phosphoglucose isomerase and PFKFB4, and has no activity against a panel of 96 kinases.
PFK15 (PFK 015) inhibits cancer cell viability (H522 cell IC50=0.72 uM) and induces apoptosis.
PFK15 (PFK 015) suppresses the glucose uptake and exhibits antitumor effects in human xenograft models.
| M.Wt | 260.29 | |
| Formula | C17H12N2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 25.2 mg/mL |
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| Chemical Name/SMILES |
2-Propen-1-one, 1-(4-pyridinyl)-3-(2-quinolinyl)- |
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1. Clem BF, et al. Mol Cancer Ther. 2013 Aug;12(8):1461-70.
2. Lea MA, et al. Anticancer Res. 2016 Apr;36(4):1479-88.
3. Zhu W, et al. PLoS One. 2016 Sep 26;11(9):e0163768.
4. Li HM, et al. J Exp Clin Cancer Res. 2017 Jan 7;36(1):7.
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