Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : PH797804
CAS No.: 586379-66-0
Catalog No.: PC-21598Not For Human Use, Lab Use Only.
PH-797804 is a potent, highly selective and ATP-competitive p38α/p38β MAPK inhibitor with IC50 of 2.3 nM (p38α).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
PH-797804 is a potent, highly selective and ATP-competitive p38α/p38β MAPK inhibitor with IC50 of 2.3 nM (p38α).
PH-797804 exhibits significant inhibition of TNFα release in hPBMC with IC50 of 3.4 nM.
PH-797804 is a readily reversible inhibitor of the alpha isoform of human p38 MAP kinase with Ki of 5.8 nM.
PH-797804 blocks inflammation-induced production of cytokines and proinflammatory mediators, such as prostaglandin E(2) in human monocyte and synovial fibroblast cell systems.
PH-797804 effectively inhibits acute inflammatory responses induced by systemically administered endotoxin in both rat and cynomolgus monkeys.
PH-797804 demonstrates robust anti-inflammatory activity in chronic disease models, significantly reducing both joint inflammation and associated bone loss in streptococcal cell wall-induced arthritis in rats and mouse collagen-induced arthritis.
| M.Wt | 477.31 | |
| Formula | C22H19BrF2N2O3 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
3-[3-bromo-4-[(2,4-difluorophenyl)methoxy]-6-methyl-2-oxopyridin-1-yl]-N,4-dimethylbenzamide |
|
1. Selness SR, et al. Bioorg Med Chem Lett. 2011 Jul 1;21(13):4066-71.
2. Hope HR, et al. J Pharmacol Exp Ther. 2009 Dec;331(3):882-95.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
