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Chemical Structure : PI3Kβ and δ inhibitor 20a
Catalog No.: PC-61135Not For Human Use, Lab Use Only.
A potent, highly selective PI3Kβ/δ inhibitor with IC50 of 7.8/5.3 nM respectively, with liitle to no activity on PI3Kα/γ (IC50=850/>10,000 nM).
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A potent, highly selective PI3Kβ/δ inhibitor with IC50 of 7.8/5.3 nM respectively, with liitle to no activity on PI3Kα/γ (IC50=850/>10,000 nM); inhibits the phosphorylation of AKT1 Ser473 in PI3K-dependent cell lines with EC50 of 3.4-7.3 nM, inhibits AKT Ser473 phosphorylation and cell viability of LNCaP tumor cells with EC50 of 7.3 nM and GI50 of 38 nM; demonstrates efficacy in human PTEN-deficient LNCaP prostate carcinoma xenograft tumor model.
| M.Wt | 450.259 | |
| Formula | C17H14Cl2FN9O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Perreault S, et al. J Med Chem. 2017 Feb 23;60(4):1555-1567.
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