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Chemical Structure : PPI-2458
Catalog No.: PC-63319Not For Human Use, Lab Use Only.
PPI-2458 is potent, specific, irreversible methionine aminopeptidase-2 (MetAP-2) inhibitor with IC50 of 0.2 nM, inhibits growth inhibition of HFLS-RA and HUVEC with IC50 of 0.04 nM.
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PPI-2458 is potent, specific, irreversible methionine aminopeptidase-2 (MetAP-2) inhibitor with IC50 of 0.2 nM, inhibits growth inhibition of HFLS-RA and HUVEC with IC50 of 0.04 nM.
PPI-2458 significantly attenuates paw swelling when therapeutically administered after the onset of chronic disease in rat model of peptidoglycan-polysaccharide-induced arthritis.
PPI-2458 exhibits potent antiproliferative activity on NHL lines in vitro (GI50=0.2-1.9 nM) and oral antitumor activity in vivo.
| M.Wt | 424.53 | |
| Formula | C22H36N2O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Bernier SG, et al. Proc Natl Acad Sci U S A. 2004 Jul 20;101(29):10768-73.
2. Hannig G, et al. Int J Oncol. 2006 Apr;28(4):955-63.
3. Cooper AC, et al. Clin Cancer Res. 2006 Apr 15;12(8):2583-90.
4. Hannig G, et al. Arthritis Rheum. 2007 Mar;56(3):850-60.
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