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Chemical Structure : Paritaprevir
CAS No.: 1216941-48-8
Catalog No.: PC-43117Not For Human Use, Lab Use Only.
Paritaprevir (ABT-450, Veruprevir) is a potent HCV NS3/4A protease inhibitor with EC50 of 1 and 0.21 nM for HCV GT 1a and 1b, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $125 | In stock | |
| 25 mg | $315 | In stock | |
| 100 mg | $785 | In stock | |
| 250 mg | Get quote |
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Paritaprevir (ABT-450, Veruprevir) is a potent HCV NS3/4A protease inhibitor with EC50 of 1 and 0.21 nM for HCV GT 1a and 1b, respectively; demonstrates in vitro antiviral activity against HCV GT1-4 and GT6 (EC50=0.09 to 19 nM), and an EC50 of 0.09 nM against GT4a; The combination of paritaprevir, ritonavir, ombitasvir (an NS5A protein inhibitor), and dasabuvir (an NS5B non-nucleoside polymerase inhibitor) with or without RBV has been approved to treat HCV genotype 1 infections.
HCV Infection
Approved
| M.Wt | 765.8771 | |
| Formula | C40H43N7O7S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Cyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a(5H)-carboxamide, N-(cyclopropylsulfonyl)-1,2,3,6,7,8,9,10,11,13a,14,15,16,16a-tetradecahydro-6-[[(5-methyl-2-pyrazinyl)carbonyl]amino]-5,16-dioxo-2-(6-phenanthridinyloxy)-, (2R,6S,12Z,13aS,14aR,16a |
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1. Schnell G, et al. Antimicrob Agents Chemother. 2015 Nov;59(11):6807-15.
2. Carrion AF, et al. Expert Opin Pharmacother. 2014 Apr;15(5):711-6.
3. Zeuzem S, et al. N Engl J Med. 2014 Apr 24;370(17):1604-14.
4. Andreone P, et al. Gastroenterology. 2014 Aug;147(2):359-365.e1.
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