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Chemical Structure : Q-VD-Oph
CAS No.: 1135695-98-5
Catalog No.: PC-42968Not For Human Use, Lab Use Only.
Q-VD-Oph is a potent pan-caspase inhibitor, inhibits human recombinant caspase-7 with IC50 of 48 nM in cell-free assay, also inhibits caspase -1, 3, 8, 9, 10, and 12 with IC50 of 25-400 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $78 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $348 | In stock | |
| 100 mg | $548 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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Q-VD-Oph is a potent pan-caspase inhibitor, inhibits human recombinant caspase-7 with IC50 of 48 nM in cell-free assay, also inhibits caspase -1, 3, 8, 9, 10, and 12 with IC50 of 25-400 nM.
Q-VD-Oph reduces doxorubicin-induced caspase-3 activation, increases expression of p21/WAF1 and senescence -associated -beta-galactosidase activity, but does not alter Akt activation.
Q-VD-Oph is significantly more effective in preventing apoptosis than the widely used inhibitors, ZVAD-fmk and Boc-D-fmk.
Q-VD-Oph prevents activated caspase-7 and caspase-cleaved fragments of tau in the TgCRND8 brain, as well as pathology associated with TgCRND8 mice.
| M.Wt | 513.49 | |
| Formula | C26H25F2N3O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 25 mg/mL |
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| Chemical Name/SMILES |
Pentanoic acid, 5-(2,6-difluorophenoxy)-3-[[(2S)-3-methyl-1-oxo-2-[(2-quinolinylcarbonyl)amino]butyl]amino]-4-oxo-, (3S)- |
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1. Caserta TM, et al. Apoptosis. 2003 Aug;8(4):345-52.
2. Rebbaa A, et al. Oncogene. 2003 May 8;22(18):2805-11.
3. Rohn TT, et al. Int J Clin Exp Med. 2009 Nov 5;2(4):300-8.
4. Renolleau S, et al. J Neurochem. 2007 Feb;100(4):1062-71.
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