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Chemical Structure : Quizartinib hydrochloride
CAS No.: 1132827-21-4
Catalog No.: PC-50013Not For Human Use, Lab Use Only.
Quizartinib (AC220) is a potent, selective, second-generation FLT3 inhibitor with Kd of 1.6 nM, inhibits Wt FLT3 and FLT3-ITD autophosphorylation in MV4-11cell with IC50 of 4.2 and 1.1 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $68 | In stock | |
| 50 mg | $118 | In stock | |
| 100 mg | $198 | In stock | |
| 500 mg | $548 | In stock |
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Quizartinib (AC220) is a potent, selective, second-generation FLT3 inhibitor with Kd of 1.6 nM, inhibits Wt FLT3 and FLT3-ITD autophosphorylation in MV4-11cell with IC50 of 4.2 and 1.1 nM, respectively; displays excellent kinase selectivity in a KinomeScan panel of 402 kinase binding assays, also potently inhibits PDGFRA, PDGFRB and RET; inhibits MV4-11 cell proliferarion with IC50 of 0.56 nM, demonstrates antitumor efficacy in the MV4-11 tumor xenograft model.
Blood Cancer
Phase 3 Clinical
| M.Wt | 633.589 | |
| Formula | C29H34Cl2N6O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-(5-tert-butyl-isoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea dihydrochloride |
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1. Zarrinkar PP, et al. Blood. 2009 Oct 1;114(14):2984-92.
2. Chao Q, et al. J Med Chem. 2009 Dec 10;52(23):7808-16.
3. Pratz KW, et al. Blood. 2010 Feb 18;115(7):1425-32.
4. Gunawardane RN, et al. Mol Cancer Ther. 2013 Apr;12(4):438-47.
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