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Chemical Structure : RIPK2-IN-8
Catalog No.: PC-60160Not For Human Use, Lab Use Only.
A potent, selective, orally available RIPK2 inhibitor with IC50 of 3 nM.
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A potent, selective, orally available RIPK2 inhibitor with IC50 of 3 nM; displays 90% percent of kinases showed <50% inhibition in a broad 250 kinase panel; effectively suppresses IL6 secrection in mouse bone marrow derived macrophages with IC50 of 12 nM; significantly reverses MDP-induced pro-inflammatory cytokines in rat colon
| M.Wt | 392.449 | |
| Formula | C18H21FN4O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. He X, et al. ACS Med Chem Lett. 2017 Sep 27;8(10):1048-1053.
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