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Chemical Structure : RORC2 inverse agonist 66
Catalog No.: PC-35886Not For Human Use, Lab Use Only.
RORC2 inverse agonist 66 is a potent, selective, and orally bioavailable RORC2 inverse agonist, significantly inhibits the IL-17 production in murine Th17 cells with 92% maximum inhibition (IC50=32 nM).
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RORC2 inverse agonist 66 is a potent, selective, and orally bioavailable RORC2 inverse agonist, significantly inhibits the IL-17 production in murine Th17 cells with 92% maximum inhibition (IC50=32 nM); displays high selectivity over 48 nuclear receptors and excellent in vitro and in vivo potency, demonstrates vivo efficacy evaluation in imiquimod-induced skin inflammation mouse model.
| M.Wt | 497.522 | |
| Formula | C26H26F3N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Wang Y, et al. J Med Chem. 2018 Dec 3. doi: 10.1021/acs.jmedchem.8b01545.
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