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Chemical Structure : RORγt inhibitor 1
Catalog No.: PC-60487Not For Human Use, Lab Use Only.
A potent, selective, orally bioavailable RORγt inverse agonist with IC50 of 17 nM in TR-FRET assays.
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A potent, selective, orally bioavailable RORγt inverse agonist with IC50 of 17 nM in TR-FRET assays; shows no inhibitory activity against the closely related nuclear hormone receptors RORα or RORβ; attenuates expression of genes such as IL26, IL23R and CCR6 in primary human Th17 cells, attenuate the knee swelling response in an antigen-induced arthritis rat models and inhibits IL-17A cytokine production in ex vivo recall assays.
| M.Wt | 475.597 | |
| Formula | C26H33N7O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Guendisch U, et al. PLoS One. 2017 Nov 20;12(11):e0188391.
2. Hintermann S, et al. ChemMedChem. 2016 Dec 16;11(24):2640-2648.
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