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Chemical Structure : RPL-554
CAS No.: 1884461-72-6
Catalog No.: PC-60220Not For Human Use, Lab Use Only.
RPL-554 (Ensifentrine, LS-193855, RPL554) is a potent, orally available, dual PDE3/PDE4 inhibitor with IC50 of 0.4 nM and 1479 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $198 | In stock | |
| 10 mg | $328 | In stock | |
| 25 mg | $528 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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RPL-554 (Ensifentrine, LS-193855, RPL554) is a potent, orally available, dual PDE3/PDE4 inhibitor with IC50 of 0.4 nM and 1479 nM, respectively.
RPL-554 inhibits LPS-induced TNFα release from human monocytes with IC50 of 0.52 uM, and proliferation of human mononuclear cells to phytohemagglutinin (IC50=0.46 uM).
RPL-554 significantly inhibits eosinophil recruitment following antigen challenge in ovalbumin-sensitized guinea pigs (10mg/kg).
| M.Wt | 477.554 | |
| Formula | C26H31N5O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(E)-1-(2-(2-(Mesitylimino)-9,10-dimethoxy-4-oxo-6,7-dihydro-2H-pyrimido[6,1-a]isoquinolin-3(4H)-yl)ethyl)urea |
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1. Boswell-Smith V, et al. J Pharmacol Exp Ther. 2006 Aug;318(2):840-8.
2. Calzetta L, et al. J Pharmacol Exp Ther. 2013 Sep;346(3):414-23.
3. Turner MJ, et al. Am J Physiol Lung Cell Mol Physiol. 2016 Jan 1;310(1):L59-70.
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