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Chemical Structure : RSL-3
CAS No.: 1219810-16-8
Catalog No.: PC-42089Not For Human Use, Lab Use Only.
GPX4 inhibitor RSL3 is an oncogenic RAS-selective lethal compound that actvates iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells, inhibits glutathione peroxidase (GPX4) and induces ferroptosis in BJeLR cells (EC50=10 nM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $138 | In stock | |
| 25 mg | $228 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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GPX4 inhibitor RSL3 is an oncogenic RAS-selective lethal compound that actvates iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells, inhibits glutathione peroxidase (GPX4) and induces ferroptosis in BJeLR cells (EC50=10 nM).
RSL3 increases PTGS2 expression and significantly inhibits tumor growth in a xenograft mouse model (100 mg/kg).
| M.Wt | 440.8763 | |
| Formula | C23H21ClN2O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 31 mg/mL |
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| Chemical Name/SMILES |
1H-Pyrido[3,4-b]indole-3-carboxylic acid, 2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1-[4-(methoxycarbonyl)phenyl]-, methyl ester, (1S,3R)- |
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1. Yang WS, et al. Chem Biol. 2008 Mar;15(3):234-45.
2. Yang WS, et al. Cell. 2014 Jan 16;156(1-2):317-331.
3. Dächert J, et al. Oncotarget. 2016 Sep 27;7(39):63779-63792.
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