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RU1968

Chemical Structure : RU1968

CAS No.: 171336-24-6

RU1968 (RU 1968;RU-1968)

Catalog No.: PC-63469Not For Human Use, Lab Use Only.

RU1968 is a potent, cross-species sperm-specific Ca2+ channel CatSper inhibitor that is selective for CatSper over Slo3.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

RU1968 is a potent, cross-species sperm-specific Ca2+ channel CatSper inhibitor that is selective for CatSper over Slo3.
RU1968 suppresses progesterone- and prostaglandin-induced Ca2+ signals in human sperm (IC50=4 and 3.8 uM).
RU1968 potently abolishes CatSper-mediated Ca2+ signals in mouse, human, and sea urchin sperm.

Physicochemical Properties

M.Wt 370.581
Formula C24H38N2O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(8R,9R,13R,14R,17R)-17-((R)-1-((2-(dimethylamino)ethyl)amino)ethyl)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-ol

References

1. Rennhack A, et al. Br J Pharmacol. 2018 May 3. doi: 10.1111/bph.14355.

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