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Chemical Structure : Rat C53 peptide
Catalog No.: PC-72560Not For Human Use, Lab Use Only.
Rat C53 peptide (C53, pGC-B activator C53) is a novel potent, selective particulate guanylyl cyclase B (pGC-B) activator, activates pGC-B/cGMP signaling pathway, and enhances cGMP generating actions.
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Rat C53 peptide (C53, pGC-B activator C53) is a novel potent, selective particulate guanylyl cyclase B (pGC-B) activator, activates pGC-B/cGMP signaling pathway, and enhances cGMP generating actions.
C53 is highly resistant to NEP degradation and has less interaction with NPRC compared to CNP in vitro.
C53 activates the protective pGC-B/cGMP signaling pathway and possesses enhanced cGMP generating actions.
C53 inhibits fibroblast proliferation chronically and suppresses the differentiation of fibroblasts to myofibroblasts.
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1. Yang Chen, et al. J Mol Cell Cardiol. 2019 May;130:140-150.
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