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Regorafenib hydrochloride

Chemical Structure : Regorafenib hydrochloride

CAS No.: 835621-07-3

Regorafenib hydrochloride (BAY73-4506 hydrochloride)

Catalog No.: PC-43483Not For Human Use, Lab Use Only.

Regorafenib hydrochloride (BAY73-4506) is a potent, orally active multikinase inhibitor that potently inhibits endothelial cell kinases in biochemical and cellular kinase phosphorylation assays with nanomolar range (IC50=3-200 nM).

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Biological Activity

Regorafenib hydrochloride (BAY73-4506) is a potent, orally active multikinase inhibitor that potently inhibits endothelial cell kinases in biochemical and cellular kinase phosphorylation assays with nanomolar range (IC50=3-200 nM).
Regorafenib hydrochloride inhibits VEGFR1/2/3, PDGFRβ, FGFR1, KIT, RET and B-RAF etc.
Regorafenib hydrochloride exhibits potent dose-dependent TGI in various preclinical human xenograft models in mice.

Physicochemical Properties

M.Wt 519.28
Formula C21H16Cl2F4N4O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 5.6 mg/mL

Chemical Name/SMILES

2-Pyridinecarboxamide, 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-, hydrochloride (1:1)

References

1. Wilhelm SM, et al. Int J Cancer. 2011 Jul 1;129(1):245-55.

2. Mross K, et al. Clin Cancer Res. 2012 May 1;18(9):2658-67.

3. Abou-Elkacem L, et al. Mol Cancer Ther. 2013 Jul;12(7):1322-31.

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