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Chemical Structure : Rezivertinib
CAS No.: 1835667-12-3
Catalog No.: PC-38343Not For Human Use, Lab Use Only.
Rezivertinib (BPI-7711) is a novel third-generation EGFR tyrosine kinase inhibitor selective for EGFR-sensitizing and T790M mutations, shows potential against T790M-mediated drug resistance.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $218 | In stock | |
| 25 mg | $398 | In stock | |
| 100 mg | $858 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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Rezivertinib (BPI-7711) is a novel third-generation EGFR tyrosine kinase inhibitor selective for EGFR-sensitizing and T790M mutations, shows potential against T790M-mediated drug resistance.
Rezivertinib (BPI-7711) specifically and covalently binds to and inhibits selective EGFR mutations, with particularly high selectivity against the T790M mutation, prevents EGFR mutant-mediated signaling and leads to cell death in EGFR mutant-expressing tumor cells.
Rezivertinib (BPI-7711) shows minimal activity against wild-type EGFR (wt EGFR), and does not cause dose-limiting toxicities that occur during the use of non-selective EGFR inhibitors, which also inhibit wt EGFR.
| M.Wt | 486.576 | |
| Formula | C27H30N6O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-[2-[2-(dimethylamino)ethoxy]-4-methoxy-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]phenyl]prop-2-enamide |
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1. Yuankai Shi, et al. J Thorac Oncol. 2022 Feb 15;S1556-0864(22)00084-3.
2. Nagasaka M, et al. J Thorac Oncol. 2021 May;16(5):740-763.
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