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Chemical Structure : Ropsacitinib
CAS No.: 2127109-84-4
Catalog No.: PC-72613Not For Human Use, Lab Use Only.
Ropsacitinib (PF-06826647) is a potent, selective TYK2 inhibitor with IC50 of 15 nM, inhibits JAK1/2/3 with IC50 of 383/74/>10,000 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $258 | In stock | |
| 10 mg | $428 | In stock | |
| 25 mg | $728 | In stock | |
| 100 mg | Get quote | ||
| 1 g | Get quote |
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Ropsacitinib (PF-06826647) is a potent, selective TYK2 inhibitor with IC50 of 15 nM, inhibits JAK1/2/3 with IC50 of 383/74/>10,000 nM.
Ropsacitinib (PF-06826647) targets and binds to the JH1 domain, inhibits IL-12 stimulated phosphorylation of STAT4 with IC50 of 14 nM.
Ropsacitinib (PF-06826647) (1-30 mg/kg, po, QD) inhibits ear swelling in the imiquimod-induced skin inflammation model.
| M.Wt | 383.419 | |
| Formula | C20H17N9 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO (3.8 mg/mL) |
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| Chemical Name/SMILES |
(1r,3r)-3-(cyanomethyl)-3-(4-(6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl)-1H-pyrazol-1-yl)cyclobutane-1-carbonitrile |
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1. Gerstenberger BS, et al. J Med Chem. 2020 Nov 25;63(22):13561-13577.
2. Singh RSP, et al. Clin Transl Sci. 2021 Mar;14(2):671-682.
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