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Runcaciguat

Chemical Structure : Runcaciguat

CAS No.: 1402936-61-1

Runcaciguat (BAY 1101042, BAY1101042)

Catalog No.: PC-36097Not For Human Use, Lab Use Only.

Runcaciguat is a potent soluble guanylyl cyclase (sGC) stimulator/activator, binds and activates oxidized and heme-free sGC and thereby restores NO-sGC-cGMP signaling under oxidative stress.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Runcaciguat is a potent, selective soluble guanylyl cyclase (sGC) stimulator/activator, binds and activates oxidized and heme-free sGC and thereby restores NO-sGC-cGMP signaling under oxidative stress.

Physicochemical Properties

M.Wt 488.328
Formula C23H22Cl2F3NO3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(3S)-3-{4-chloro-3-[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanamido]phenyl}-3-cyclopropylpropanoic acid

References

1. PCT Int. Appl. (2018), WO 2018153899 A1 20180830.

2. PCT Int. Appl. (2012), WO 2012139888 A1 20121018.

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