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Chemical Structure : S-3448
Catalog No.: PC-61609Not For Human Use, Lab Use Only.
S-3448 is a potent, specific soluble guanylate cyclase (sGC) activator with EC50 of 0.68 uM, preferentially activates the NO-insensitive heme-oxidized form of sGC.
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S-3448 is a potent, specific soluble guanylate cyclase (sGC) activator with EC50 of 0.68 uM, preferentially activates the NO-insensitive heme-oxidized form of sGC.
S-3448 increases cGMP levels in cultured rat aortic smooth muscle cells.
S-3448 induces vasorelaxation of isolated endothelium-denuded rat aorta, porcine coronary arteries, and human corpus cavernosum with EC50 of 1-10 uM, elicits phosphorylation of the cGMP kinase substrate vasodilator-stimulated phosphoprotein at Ser239.
| M.Wt | 612.127 | |
| Formula | C25H26ClN3O7S3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Schindler U, et al. Mol Pharmacol. 2006 Apr;69(4):1260-8.
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