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Chemical Structure : SB-222200
CAS No.: 174635-69-9
Catalog No.: PC-44659Not For Human Use, Lab Use Only.
A CNS-penetrant, potent and selective NK-3 receptor antagonist with Ki of 4.4 nM (inhibition of neurokinin B binding to CHO-hNK-3R).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 50 mg | $448 | In stock | |
| 250 mg | Get quote |
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A CNS-penetrant, potent and selective NK-3 receptor antagonist with Ki of 4.4 nM (inhibition of neurokinin B binding to CHO-hNK-3R); good selectivity for hNK-3 over hNK-1 (Ki >10 uM) and hNK-2 (Ki=250 nM); produces dose-dependent inhibition of behavioral responses induced by Senktide; orally bioactive.
| M.Wt | 380.4816 | |
| Formula | C26H24N2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-Quinolinecarboxamide, 3-methyl-2-phenyl-N-[(1S)-1-phenylpropyl]- |
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1. Sarau HM, et al. J Pharmacol Exp Ther. 2000 Oct;295(1):373-81.
2. Nwaneshiudu CA, et al. Neuropharmacology. 2009 Sep;57(3):295-301.
3. De Brito Gariepy H, et al. Br J Pharmacol. 2010 Dec;161(8):1868-84.
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