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Chemical Structure : SB-225002
CAS No.: 182498-32-4
Catalog No.: PC-45057Not For Human Use, Lab Use Only.
SB-225002 (SB225002) is a potent, selective, non-peptide CXCR2 antagonist with IC50 of 22 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $198 | In stock | |
| 100 mg | $498 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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SB-225002 (SB225002) is a potent, selective, non-peptide CXCR2 antagonist with IC50 of 22 nM.
SB-225002 displays >150-fold selectivity over CXCR1.
SB-225002 potently inhibits human and rabbit neutrophil chemotaxis induced by both IL-8 and GROalpha in vitro.
SB-225002 selectively blocks IL-8-induced neutrophil margination in rabbits.
| M.Wt | 352.1402 | |
| Formula | C13H10BrN3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Urea, N-(2-bromophenyl)-N'-(2-hydroxy-4-nitrophenyl)- |
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1. White JR, et al. J Biol Chem. 1998 Apr 24;273(17):10095-8.
2. Auten RL, et al. J Pharmacol Exp Ther. 2001 Oct;299(1):90-5.
3. Manjavachi MN, et al. Eur J Pain. 2010 Jan;14(1):23-31.
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