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Chemical Structure : SB-431542
CAS No.: 301836-41-9
Catalog No.: PC-42581Not For Human Use, Lab Use Only.
SB-431542 is a potent, specific TGF-β type I receptor (ALK5) inhibitor with IC50 of 94 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $148 | In stock | |
| 50 mg | $258 | In stock | |
| 100 mg | Get quote |
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SB-431542 is a potent, specific TGF-β type I receptor (ALK5) inhibitor with IC50 of 94 nM.
SB-431542 also substantially inhibits ALK4 and 7, but not other ALKs.
SB-431542 efficiently inhibits the ability of activated ALK4, ALK5, and ALK7 to phosphorylate Smad2.
SB-431542 is a selective inhibitor of endogenous activin and TGF-beta signaling but has no effect on BMP signaling, and has no effect on components of the ERK, JNK, or p38 MAP kinase pathways.
| M.Wt | 384.3875 | |
| Formula | C22H16N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 40 mg/mL; Ethanol: 11.17 mg/mL (Need ultrasonic and warming) |
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| Chemical Name/SMILES |
Benzamide, 4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]- |
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1. Callahan JF, et al. J Med Chem. 2002 Feb 28;45(5):999-1001.
2. Inman GJ, et al. Mol Pharmacol. 2002 Jul;62(1):65-74.
3. Matsuyama S, et al. Cancer Res. 2003 Nov 15;63(22):7791-8.
4. Hjelmeland MD, et al. Mol Cancer Ther. 2004 Jun;3(6):737-45.
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