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Chemical Structure : SB772077B
CAS No.: 785774-34-7
Catalog No.: PC-35737Not For Human Use, Lab Use Only.
SB772077B (SB-772077B, SB77, SB-772077-B) is a potent, selective Rho kinase (ROCK) inhibitor with IC50 of 5.6 nM and 6.0 nM for ROCK1 and ROCK2, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $198 | In stock | |
| 10 mg | $328 | In stock | |
| 25 mg | $528 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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SB772077B (SB-772077B, SB77, SB-772077-B) is a potent, selective Rho kinase (ROCK) inhibitor with IC50 of 5.6 nM and 6.0 nM for ROCK1 and ROCK2, respectively.
SB772077B blocks the generation of inflammatory cytokines, such as IL-6 and TNF-alpha.
SB772077B induces vasorelaxation in preconstricted rat aorta with IC50 of 39 nM; produces a profound dose-dependent reduction of systemic blood pressure in spontaneously hypertensive rats.
| M.Wt | 342.363 | |
| Formula | C15H18N8O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-(7-{[(3S)-3-amino-1-pyrrolidinyl]carbonyl}-1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-amine |
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1. Doe C, et al. J Pharmacol Exp Ther. 2007 Jan;320(1):89-98.
2. Ashwinbalaji S, et al. Sci Rep. 2018 Oct 19;8(1):15472.
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