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Chemical Structure : SBC 115076
CAS No.: 489415-96-5
Catalog No.: PC-63171Not For Human Use, Lab Use Only.
SBC 115076 is a PCSK9 modulator that blocks LDLR degradation in HEK293T cells expressing PCSK9, increase the uptake of LDL by liver cells in vitro at submicromolar concentrations.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $188 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | $488 | In stock | |
| 100 mg | Get quote |
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SBC 115076 is a PCSK9 modulator that blocks LDLR degradation in HEK293T cells expressing PCSK9, increase the uptake of LDL by liver cells in vitro at submicromolar concentrations.
SBC 115076 effectively lowers cholesterol levels in high fat diet mice.
| M.Wt | 527.621 | |
| Formula | C31H33N3O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-(4-(benzyloxy)-3-methylbenzoyl)-3-hydroxy-1-(3-morpholinopropyl)-5-(pyridin-4-yl)-1,5-dihydro-2H-pyrrol-2-one |
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1. Daniel Pettersen, et al. Small molecule modulators of PCSK9-a literature and patent overview. Bioorg Med Chem Lett. 2018 Feb 26. pii: S0960-894X(18)30151-3.
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