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Chemical Structure : SBP7455
CAS No.: 1884222-74-5
Catalog No.: PC-21693Not For Human Use, Lab Use Only.
SBP-7455 is a potent, selective and orally active ULK1/2 inhibitor with IC50 of 13 nM (ULK1) and 476 nM (ULK2) in ADP-Glo assays, selectively blocks autophagic flux in TNBC cell lines.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | $528 | In stock | |
| 100 mg | Get quote |
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SBP-7455 is a potent, selective and orally active ULK1/2 inhibitor with IC50 of 13 nM (ULK1) and 476 nM (ULK2) in ADP-Glo assays, selectively blocks autophagic flux in TNBC cell lines.
SBP-7455 blocks phosphorylation of downstream autophagy target proteins Beclin1 and VPS34.
SBP-7455 is an efficacious tool that can be used to modulate autophagy in vivo.
SBP-7455 is cytotoxic as single agents against TNBC cells with IC50 of 0.3 uM for MDA-MB-468 cells, which is more potent than SBI-0206965.
SBP-7455 promotes apoptosis in TNBC cells under nutrient-deprived conditions.
SBP-7455 reduces autophagic flux and exhibits synergistic cytotoxicity with the PARP inhibitor olaparib against MDA-MB-468 cells, reverses olaparib-induced autophagic flux.
| M.Wt | 354.33 | |
| Formula | C16H17F3N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N4-Cyclopropyl-N2-(3,4-dimethoxyphenyl)-5-(trifluoromethyl)pyrimidine-2,4-diamine |
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1. Huiyu Ren, et al. J Med Chem. 2020 Dec 10;63(23):14609-14625.
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