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Chemical Structure : SCH-527123
CAS No.: 473727-83-2
Catalog No.: PC-42443Not For Human Use, Lab Use Only.
SCH-527123 (Navarixin, MK-7123) is a potent, selective, orally bioavailable CXCR2/CXCR1 receptor antagonist with Kd of 0.08 and 41 nM for cynomolgus CXCR2 and CXCR1, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $148 | In stock | |
| 25 mg | $248 | In stock | |
| 50 mg | $398 | In stock | |
| 100 mg | Get quote |
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SCH-527123 (Navarixin, MK-7123) is a potent, selective, orally bioavailable CXCR2/CXCR1 receptor antagonist with Kd of 0.08 and 41 nM for cynomolgus CXCR2 and CXCR1, respectively.
SCH-527123 potently inhibits CXCR2-mediated chemotaxis with IC50 of 3-6 nM.
SCH-527123 inhibits neutrophil recruitment, mucus production, and goblet cell hyperplasia in animal models of pulmonary inflammation.
| M.Wt | 397.4244 | |
| Formula | C21H23N3O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Benzamide, 2-hydroxy-N,N-dimethyl-3-[[2-[[(1R)-1-(5-methyl-2-furanyl)propyl]amino]-3,4-dioxo-1-cyclobuten-1-yl]amino]- |
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1. Chapman RW, et al. J Pharmacol Exp Ther. 2007 Aug;322(2):486-93.
2. Dwyer MP, et al. J Med Chem. 2006 Dec 28;49(26):7603-6.
3. Gonsiorek W, et al. J Pharmacol Exp Ther. 2007 Aug;322(2):477-85.
4. Singh S, et al. Clin Cancer Res. 2009 Apr 1;15(7):2380-6.
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