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Chemical Structure : SCR7
CAS No.: 1533426-72-0
Catalog No.: PC-43167Not For Human Use, Lab Use Only.
SCR7 is a specific inhibitor of nonhomologous end-joining (NHEJ), blocks Ligase IV-mediated joining by interfering with its DNA binding but not that of T4 DNA Ligase or Ligase I.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $75 | In stock | |
| 25 mg | $215 | In stock | |
| 100 mg | $455 | In stock | |
| 500 mg | Get quote |
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SCR7 is a specific inhibitor of nonhomologous end-joining (NHEJ), blocks Ligase IV-mediated joining by interfering with its DNA binding but not that of T4 DNA Ligase or Ligase I; inhibits NHEJ in a Ligase IV-dependent manner within cells, causes accumulation of double-strand breaks (DSBs), and activates the intrinsic apoptotic pathway; decreases cell proliferation of MCF7, A549, and HeLa with IC50 of 40, 34, and 44 uM, respectively; increases the efficacy of DSB-inducing therapeutic modalities in mouse xenografts; increases the efficiency of precise genome editing with CRISPR-Cas9 in mammalian cell lines and in mice.
| M.Wt | 334.395 | |
| Formula | C18H14N4OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 45 mg/mL |
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| Chemical Name/SMILES |
4(1H)-Pyrimidinone, 2,3-dihydro-5,6-bis[(phenylmethylene)amino]-2-thioxo- |
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1. Srivastava M, et al. Cell. 2012 Dec 21;151(7):1474-87.
2. Greco GE, et al. DNA Repair (Amst). 2016 Jul;43:18-23.
3. Maruyama T, et al. Nat Biotechnol. 2015 May;33(5):538-42.
4. Gkotzamanidou M, et al. Blood. 2016 Sep 1;128(9):1214-25.
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