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Chemical Structure : SHU-9119
Catalog No.: PC-70059Not For Human Use, Lab Use Only.
A potent melanocortin MC3 and MC4 receptor antagonist with IC50 of 0.23 nM and 0.06 nM, respectively.
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A potent melanocortin MC3 and MC4 receptor antagonist with IC50 of 0.23 nM and 0.06 nM, respectively; also is an MC5 partial agonist (EC50 = 0.12 nM); upregulates expression of genes promoting lipogenesis and triglyceride storage (SCD1, LPL, ACCα and FAS), increases triglyceride synthesis and promotes insulin resistance; increases food intake, body weight and fat mass when administered centrally in vivo.
| M.Wt | 1074.258 | |
| Formula | C54H71N15O9 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Hruby VJ, et al. J Med Chem. 1995 Sep 1;38(18):3454-61.
2. Fan W, et al. Nature. 1997 Jan 9;385(6612):165-8.
3. Huang QH, et al. J Neurosci. 1997 May 1;17(9):3343-51.
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