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Chemical Structure : SP-13786
CAS No.: 1448440-52-5
Catalog No.: PC-42224Not For Human Use, Lab Use Only.
SP-13786 is a highly potent, selective, orally bioavailable inhibitor of fibroblast activation protein (FAP) with IC50 of 3.2 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $188 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | $488 | In stock | |
| 100 mg | Get quote |
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SP-13786 is a highly potent, selective, orally bioavailable inhibitor of fibroblast activation protein (FAP) with IC50 of 3.2 nM.
SP-13786 displays high selectivity against the related DPPs: DPPIV, DPP9, DPPII, and PREP (IC50=1.8 uM).
SP-13786 demonstrates high oral bioavailability, plasma half-life, and the potential to selectively and completely inhibit FAP in vivo.
| M.Wt | 344.3155 | |
| Formula | C17H14F2N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-Quinolinecarboxamide, N-[2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-2-oxoethyl]- |
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1. Jansen K, et al. J Med Chem. 2014 Apr 10;57(7):3053-74.
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