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SR-11302

Chemical Structure : SR-11302

CAS No.: 160162-42-5

SR-11302 (SR11302)

Catalog No.: PC-38608Not For Human Use, Lab Use Only.

SR-11302( SR11302) is a specific, small molecule inhibitor of activator protein-1 (AP-1), inhibits AP-1 activity without activating the transcription of RARE.

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Biological Activity

SR-11302( SR11302) is a specific, small molecule inhibitor of activator protein-1 (AP-1), inhibits AP-1 activity without activating the transcription of RARE.
SR-11302 inhibits tumor promotion in AP-1-luciferase transgenic mice, inhibits papilloma formation during the course of the tumor promotion.
SR-11302 blocks TPA-induced AP-1 transactivation in AP-1-luciferase transgenic mice.
SR-11302 decreases VEGF promoter activity and downregulates c-Fos expression and release.
SR-11302 reduces metastatic lesion formation in the 4D model of lung cancer.

Physicochemical Properties

M.Wt 376.540
Formula C26H32O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-methyl-7-(4-methylphenyl)-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoic acid

References

1. Maron BA, et al. Circulation. 2014 Jul 8;130(2):168-79.

2. Huang C, et al. Proc Natl Acad Sci U S A. 1997 May 27;94(11):5826-30.

3. Li JJ, et al. Cancer Res. 1997 Aug 15;57(16):3569-76.

4. Catar R, et al. Kidney Int. 2013 Dec;84(6):1119-28.

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