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Chemical Structure : SR-1664
Catalog No.: PC-60333Not For Human Use, Lab Use Only.
A novel potent, non-agonist PPARγ ligand that blocks the Cdk5-mediated phosphorylation in vitro (IC50=80 nM) and in vivo, without the classical agonism.
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A novel potent, non-agonist PPARγ ligand that blocks the Cdk5-mediated phosphorylation in vitro (IC50=80 nM) and in vivo, without the classical agonism; exhibits potent anti-diabetic activity while not causing the fluid retention and weight gain that are serious side effects of many of the PPARγ drugs; effectively improves glucose homeostasis, and does not affect bone cell mineralization in culture.
| M.Wt | 547.6 | |
| Formula | C33H29N3O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
100 mM in DMSO |
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1. Choi JH, et al. Nature. 2011 Sep 4;477(7365):477-81.
2. Choi SS, et al. J Biol Chem. 2014 Sep 19;289(38):26618-29.
3. Marciano DP, et al. Nat Commun. 2015 Jun 12;6:7443.
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