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STF-62247

Chemical Structure : STF-62247

CAS No.: 315702-99-9

STF-62247 (STF62247;STF 62247)

Catalog No.: PC-42248Not For Human Use, Lab Use Only.

STF-62247 is a small molecule Autophagy inducer that induces autophagy and selectively induces lethality in VHL-deficient RCC cells.

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Biological Activity

STF-62247 is a small molecule Autophagy inducer that induces autophagy and selectively induces lethality in VHL-deficient RCC cells.
STF-62247 induces cytotoxicity and reduces tumor growth in VHL-deficient cells in a HIF-independent manner, PI3K and Golgi trafficking are required as initial signals in STF-62247-induced autophagy.

Physicochemical Properties

M.Wt 267.3488
Formula C15H13N3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
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Solubility

DMSO: ≥ 31 mg/mL

Chemical Name/SMILES

2-Thiazolamine, N-(3-methylphenyl)-4-(4-pyridinyl)-

References

1. Turcotte S, et al. Cancer Cell. 2008 Jul 8;14(1):90-102.

2. Turcotte S, et al. Autophagy. 2008 Oct;4(7):944-6.

3. Chan DA, et al. Cell Cycle. 2008 Oct;7(19):2987-90.

4. Kozako T, et al. Oncotarget. 2018 Jun 12;9(45):27645-27655.

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