Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : SU5416
CAS No.: 204005-46-9
Catalog No.: PC-42557Not For Human Use, Lab Use Only.
A potent and specific VEGFR2 (KDR/Flk-1) inhibitor with IC50 of 1.04 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 50 mg | $152 | In stock | |
| 100 mg | $200 | In stock |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
A potent and specific VEGFR2 (KDR/Flk-1) inhibitor with IC50 of 1.04 uM; displays no inhibitory activity against EGFR and FGFR; inhibits autophosphorylation of the Flk-1 receptor with IC50 of 1.23 uM in ELISA assays, inhibits VEGF-driven mitogenesis of HUVECs with IC50 of 0.04 uM; affects tumor vascular density and vascular leakage in vivo.
Solid Tumors
Phase 1 Discontinued
| M.Wt | 238.2845 | |
| Formula | C15H14N2O | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
DMSO: 22.5 mg/mL |
|
| Chemical Name/SMILES |
2H-Indol-2-one, 3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro- |
|
1. Fong TA, et al. Cancer Res. 1999 Jan 1;59(1):99-106.
2. Shaheen RM, et al. Cancer Res. 1999 Nov 1;59(21):5412-6.
3. Mendel DB, et al. Anticancer Drug Des. 2000 Feb;15(1):29-41.
4. Mendel DB, et al. Clin Cancer Res. 2000 Dec;6(12):4848-58.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
