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SW-106

Chemical Structure : SW-106

CAS No.: 1027921-53-4

SW-106 (SW 106;SW106)

Catalog No.: PC-70262Not For Human Use, Lab Use Only.

A potent, selective, competitive PTH/PTH-related peptide receptor (PPR) antagonist with IC50 of 0.99 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

A potent, selective, competitive PTH/PTH-related peptide receptor (PPR) antagonist with IC50 of 0.99 uM; displays higher affinity for the PPR relative to the other GPCRs; specificly blocks PTH-initiated cAMP accumulation.

Physicochemical Properties

M.Wt 361.312
Formula C17H16F5NO2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(3S,5S)-5-((E)-2-cyclopropylvinyl)-3-ethyl-6,7-difluoro-5-(trifluoromethyl)-1,5-dihydrobenzo[e][1,4]oxazepin-2(3H)-one

References

1. Carter PH, et al. Proc Natl Acad Sci U S A. 2007 Apr 17;104(16):6846-51.

2. Carter PH, et al. Mol Endocrinol. 2015 Feb;29(2):307-21.

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