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SW106065

Chemical Structure : SW106065

CAS No.: 62289-81-0

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SW106065 (SW 106065;MPNST-IN-21)

Catalog No.: PC-61648Not For Human Use, Lab Use Only.

SW106065 (CPD A) is a broad influenza virus inhibitor acting via IMP dehydrogenase (IMPDH), also is an apoptosis inducer in MPNST (malignant peripheral nerve sheath tumors) with EC50 of 1 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    SW106065 (CPD A) is a broad influenza virus inhibitor acting via IMP dehydrogenase (IMPDH), also is an apoptosis inducer in MPNST (malignant peripheral nerve sheath tumors) with EC50 of 1 uM.
    SW106065 inhibits ATP consumption of sMPNST and other models of MPNST with EC50 of 1 uM, shows no toxicity to normally dividing Schwann cells or mouse embryonic fibroblasts; reduces MPNST burden in a mouse allograft model.CPD A inhibits RNA synthesis of IAV and IBV with EC50 values of 2.3 μM and 2.6 μM, respectively.
    SW106065 also displays robust in vitro activity against a broad panel of IAV (H1N1 and H3N2) and IBV strains with median EC50 of 0.2 uM, with no significant cytotoxic effect.
    SW106065 inhibits IMP dehydrogenase (IMPDH) and causes strong depletion of the cellular GTP pool.
    SW106065 exhibits strongly synergistic effect when combined with another IMPDH inhibitor ribavirin.
    shows no toxicity to normally dividing Schwann cells or mouse embryonic fibroblasts, reduces MPNST burden in a mouse allograft model.

    Physicochemical Properties

    M.Wt 204.247
    Formula C10H8N2OS
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(pyridin-3-yl)thiophene-2-carboxamide

    References

    1. Chau V, et al. Cancer Res. 2014 Jan 15;74(2):586-97.

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