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Chemical Structure : Sapanisertib
CAS No.: 1224844-38-5
Catalog No.: PC-43497Not For Human Use, Lab Use Only.
Sapanisertib (INK-128, MLN0128, TAK-228) is a potent, ATP-competitive, orally active dual mTORC1/2 inhibitor with Ki of 1.4 nM in cell-free assays, >200-fold selectivity over calss I PI3K isoforms.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $178 | In stock | |
| 100 mg | $388 | In stock | |
| 500 mg | $848 | In stock | |
| 1 g | Get quote |
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Sapanisertib (INK-128, MLN0128, TAK-228) is a potent, ATP-competitive, orally active dual mTORC1/2 inhibitor with Ki of 1.4 nM in cell-free assays, >200-fold selectivity over calss I PI3K isoforms.
Sapanisertib (INK-128, MLN0128) inhibits both the phosphorylation of S6 and 4EBP1, the downstream substrates of TORC1, and selectively inhibits AKT phosphorylation at Ser473, the downstream substrate of TORC2.
Sapanisertib (INK-128, MLN0128) also shows potent inhibition effects on cell lines resistant to rapamycin and pan-PI3K inhibitors.
Sapanisertib (INK-128, MLN0128) shows tumor growth inhibition efficacy in multiplexenograft models.
| M.Wt | 309.33 | |
| Formula | C15H15N7O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 3-(2-amino-5-benzoxazolyl)-1-(1-methylethyl)- |
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1. Hsieh AC, et al. Nature. 2012 Feb 22;485(7396):55-61.
2. Gökmen-Polar Y, et al. Breast Cancer Res Treat.
3. Maiso P, et al. Blood. 2011 Dec 22;118(26):6860-70.
4. Janes MR, et al. Leukemia. 2013 Mar;27(3):586-94.
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