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Chemical Structure : Saracatinib
CAS No.: 379231-04-6
Catalog No.: PC-42475Not For Human Use, Lab Use Only.
Saracatinib (AZD0530) is a potent, highly selective, orally available, dual Src/Abl kinase inhibitor with IC50 of 2.7, 4, 4 and 30 nM for c-Src, Yes, Lck and Abl, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | $468 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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Saracatinib (AZD0530) is a potent, highly selective, orally available, dual Src/Abl kinase inhibitor with IC50 of 2.7, 4, 4 and 30 nM for c-Src, Yes, Lck and Abl, respectively.
Saracatinib (AZD0530) displays high selectivity over a range of kinases (Csk, VEGFR-2, Flt-4, EGFR, and PDGFR).
Saracatinib (AZD0530) exhibits potent inhibition of tumor growth in a c-Src-transfected 3T3-fibroblast xenograft model in vivo.
| M.Wt | 542.0265 | |
| Formula | C27H32ClN5O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 32 mg/mL |
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| Chemical Name/SMILES |
4-Quinazolinamine, N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methyl-1-piperazinyl)ethoxy]-5-[(tetrahydro-2H-pyran-4-yl)oxy]- |
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1. Hennequin LF, et al. J Med Chem. 2006 Nov 2;49(22):6465-88.
2. Herynk MH, et al. Mol Cancer Ther. 2006 Dec;5(12):3023-31.
3. Chang YM, et al. Oncogene. 2008 Oct 23;27(49):6365-75.
4. Gwanmesia PM, et al. BMC Cancer. 2009 Feb 13;9:53.
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