Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : T-448 free base
Catalog No.: PC-35903Not For Human Use, Lab Use Only.
T-448 free base (T448) is a specific inhibitor of LSD1 enzyme activity, enhances H3K4 methylation in primary cultured rat neurons but has little impact on LSD1-GFI1B complex in human TF-1a erythroblasts.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
T-448 free base (T448) is a specific inhibitor of LSD1 enzyme activity, enhances H3K4 methylation in primary cultured rat neurons but has little impact on LSD1-GFI1B complex in human TF-1a erythroblasts.
T-448 increases brain H3K4 methylation and partially restored learning function in mice with NMDA receptor hypofunction.
T-448 shows unique therapeutic approaches for central nervous system disorders associated with epigenetic dysregulation.
| M.Wt | 328.434 | |
| Formula | C17H20N4OS | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Matsuda S, et al. Neuropsychopharmacology. 2018 Dec 22. doi: 10.1038/s41386-018-0300-9.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
