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Chemical Structure : TC G-1008
CAS No.: 1621175-65-2
Catalog No.: PC-60593Not For Human Use, Lab Use Only.
TC G-1008 is a potent, selective, orally bioavailable GPR39 agonist with EC50 of 0.4 and 0.8 nM for rat and human GPR39, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $228 | In stock | |
| 100 mg | $598 | In stock | |
| 250 mg | Get quote | ||
| 1 g | Get quote |
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TC G-1008 is a potent, selective, orally bioavailable GPR39 agonist with EC50 of 0.4 and 0.8 nM for rat and human GPR39, respectively.
TC G-1008 displays high selectivity over a broad panel of kinases (IC50> 10 uM), and ghrelin and neurotensin-1 receptors (IC50>30 uM).
TC G-1008 robustly induces acute GLP-1 levels and shows the potential oral treatment of type 2 diabetes.
| M.Wt | 418.9 | |
| Formula | C18H19ClN6O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
100 mM in DMSO |
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| Chemical Name/SMILES |
N-[3-Chloro-4-[[[2-(methylamino)-6-(2-pyridinyl)-4-pyrimidinyl]amino]methyl]phenyl]methanesulfonamide |
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1. Młyniec K, et al. J Affect Disord. 2016 Sep 1;201:179-84.
2. Sato S, et al. Mol Pharmacol. 2016 Dec;90(6):726-737.
3. Shimizu Y, et al. Biochem Pharmacol. 2017 Sep 15;140:105-114.
4. Peukert S, et al. ACS Med Chem Lett. 2014 Aug 4;5(10):1114-8.
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