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Chemical Structure : TCV-309
Catalog No.: PC-70117Not For Human Use, Lab Use Only.
A highly potent and selective platelet activating factor (PAF) antagonist.
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A highly potent and selective platelet activating factor (PAF) antagonist; inhibits PAF-induced aggregation of rabbit and human platelets with IC50s of 33 nM and 55 nM respectively; potently protects mice from death induced by PAF and due to anaphylactic shock with ED50 of 2.1 and 2.6 ug/kg (i.v.), respectively; also reverses PAF-induced hypotension and endotoxin-induced hypotension in rats.
Coagulation Disorder
Phase 2 Discontinued
| M.Wt | 656.534 | |
| Formula | C30H34BrN5O7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Terashita Z, et al. J Pharmacol Exp Ther. 1992 Feb;260(2):748-55.
2. Motoyama N, et al. Eur J Pain. 2013 Sep;17(8):1156-67.
3. Kuipers B, et al. J Immunol. 1994 Mar 1;152(5):2438-46.
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