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Chemical Structure : TJ-M2010-2
Catalog No.: PC-20347Not For Human Use, Lab Use Only.
TJ-M2010-2 is a small molecule inhibitor of MyD88 homodimerization, interacts with MyD88 TIR domain.
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TJ-M2010-2 is a small molecule inhibitor of MyD88 homodimerization, interacts with MyD88 TIR domain.
TJ-M2010-2 partially inhibited MyD88 homodimerization at 10 μM and completely inhibited MyD88 homodimerization at 40 μM.
TJ-M2010-2 alone or with CD154 antagonist mAb MR1 improves survival rate, prevents renal dysfunction and attenuates pathologic damage after IRI.
TJ-M2010-2 alone or with MR1 decreases IRI-induced apoptosis, inhibits DC maturation in vitro and decreases DC-mediated T-cell proliferation.
TJ-M2010-2 attenuates renal fibrosis after IRI and prevents EMT in vitro.
TJ-M2010-2 down-regulates the TLR/MyD88 signaling pathway.
| M.Wt | 392.52 | |
| Formula | C22H24N4OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Zhang LM, et al. Sci Rep. 2016 Jun 1;6:26954. doi: 10.1038/srep26954.
2. Liu JH, et al. Exp Cell Res. 2020 Sep 15;394(2):112157.
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